PHH3 as an Ancillary Mitotic Marker in Gastrointestinal Stromal Tumors
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چکیده
منابع مشابه
PHH3 as an Ancillary Mitotic Marker in Gastrointestinal Stromal Tumors
BACKGROUND Counting mitoses is subjective and time-consuming. The adjunctive diagnostic utility of a recently reported mitotic marker, phosphohistone H3 (PHH3), was investigated in gastrointestinal stromal tumors (GISTs). METHODS We reviewed 77 GISTs for several proliferative indices. These included the mitotic count per 50 high power fields (HPFs), the immunohistochemical Ki- 67 labeling ind...
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OBJECTIVES Accurate grading of gastrointestinal stromal tumors (GISTs), based on mitotic index, can be problematic. METHODS In this study, we compared interobserver variability in detecting mitosis on H&E with PHH3 immunohistochemistry (IHC). In addition, we examined the correlation between H&E mitosis and Ki-67 and the association of PHH3 and Ki-67 with overall survival. Four pathologists in...
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BACKGROUND Circulating tumor cells (CTC) are prognostic and predictive for several cancer types. Only limited data exist regarding prognostic or predictive impact of CTC on gastrointestinal stromal tumor (GIST) patients. The aim of our study was to elucidate the role of CTC in GIST patients. RESULTS A total of 121 GIST patients and 54 non-GIST samples were enrolled in the study. The cutoff va...
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Gastrointestinal stromal tumors (GISTs) rarely occur in pediatric patients, but increased recognition of adult GIST has led to better awareness of the existence of this entity in the pediatric population. GIST occurring in pediatric patients has a unique biology and clinical behavior and warrants discussion as an independent entity. The generally accepted definition of pediatric GIST is a tumor...
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ژورنال
عنوان ژورنال: Journal of Pathology and Translational Medicine
سال: 2015
ISSN: 2383-7837,2383-7845
DOI: 10.4132/jptm.2014.10.08